PT-141 (Bremelanotide – Melanocortin Receptor Agonist)

PT-141 is a synthetic analog of α-melanocyte-stimulating hormone (α-MSH) and a potent melanocortin-4 receptor (MC4R) agonist. Unlike phosphodiesterase inhibitors that act peripherally, PT-141 exerts its effects centrally, directly activating neural pathways in the hypothalamus associated with sexual desire and arousal

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Key Research Features

  • Central-nervous activation: Stimulates MC4R in the hypothalamic preoptic area to induce sexual motivation.
  • Gender-independent efficacy: Increases arousal behaviors in both male and female animal models.
  • Dopaminergic interplay: Enhances dopamine release in mesolimbic circuits involved in reward and motivation.
  • Cardiovascular neutrality: Acts without significant impact on blood pressure or heart rate at research doses.
  • Synergistic studies: Evaluated in combination with oxytocin for compounded neurosexual response.
  • Human trial correlation: Demonstrated improvements in desire and satisfaction scores in controlled studies.

Research Applications

  • Sexual-motivation and reward-pathway research
  • Hypothalamic MC4R and dopamine-network modeling
  • Erectile and female-arousal mechanism studies
  • Neuroendocrine and behavioral-response assays

Research Classification

For laboratory research only. Not for human or animal use.

Storage & Handling

Store –20 °C (dry). Reconstitute under sterile conditions. Use within standard stability limits after reconstitution

All products offered by PureGeniX Wellness are intended for research and educational purposes only. These compounds have not been evaluated or approved by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Information provided on this site is for research, education, and informational purposes only and should not be interpreted as medical advice. Always consult your licensed healthcare provider regarding any medical concerns or before starting any wellness protocol.

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