MOTS-c (Mitochondrial-Derived Peptide)

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring mitochondrial peptide that plays a regulatory role in cellular metabolism, energy expenditure, and stress adaptation. It is encoded by mitochondrial DNA and has been studied for its influence on glucose utilization and resistance to metabolic stress.

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Key Research Features

  • Mitochondrial regulation: Modulates nuclear gene expression related to metabolism and cellular stress.
  • Glucose homeostasis: Enhances insulin sensitivity and glucose uptake in cell-culture models.
  • AMPK activation: Stimulates AMP-activated protein kinase pathways for energy balance research.
  • Metabolic adaptation: Involved in mitochondrial-to-nuclear communication (“retrograde signaling”).
  • Exercise-mimetic potential: Promotes fat oxidation and metabolic resilience under load.
  • Cellular protection: Demonstrated attenuation of oxidative and inflammatory stress in vitro.

Research Applications

  • Mitochondrial signaling and bioenergetic modeling
  • Metabolic-syndrome and insulin-resistance studies
  • Stress-response and cellular-aging investigations
  • Gene-expression and AMPK-pathway analysis

Research Classification

For laboratory research only. Not for human or animal use.

Storage & Handling

Store –20 °C (dry). Reconstitute under sterile conditions. Use within standard stability limits after reconstitution

All products offered by PureGeniX Wellness are intended for research and educational purposes only. These compounds have not been evaluated or approved by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Information provided on this site is for research, education, and informational purposes only and should not be interpreted as medical advice. Always consult your licensed healthcare provider regarding any medical concerns or before starting any wellness protocol.

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