KPV (α-MSH Tripeptide Fragment)

KPV is a naturally occurring tripeptide fragment (Lys-Pro-Val) derived from the C-terminal of α-melanocyte-stimulating hormone (α-MSH). It has been investigated for its potent anti-inflammatory and epithelial-barrier protective properties.

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Key Research Features

  • Melanocortin-pathway activity: Engages MC1R receptors involved in immunomodulation.
  • Cytokine regulation: Downregulates NF-κB and IL-1β signaling in cell-culture models.
  • Barrier-function studies: Restores epithelial integrity in gut- and skin-cell assays.
  • Topical and systemic relevance: Explored in both localized and systemic inflammatory conditions.
  • Endothelial protection: Reduces reactive oxygen species (ROS) formation in vascular models.
  • Synergy with BPC/TB: Supports multi-pathway repair when combined in blended studies.

Research Applications

  • Inflammatory and immune-response modeling
  • Gut-epithelium and skin-barrier studies
  • Cytokine and NF-κB pathway analysis
  • Oxidative stress and tissue-protection assays

Research Classification

For laboratory research only. Not for human or animal use.

Storage & Handling

Store –20 °C (dry). Reconstitute under sterile conditions. Use within standard stability limits after reconstitution

All products offered by PureGeniX Wellness are intended for research and educational purposes only. These compounds have not been evaluated or approved by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Information provided on this site is for research, education, and informational purposes only and should not be interpreted as medical advice. Always consult your licensed healthcare provider regarding any medical concerns or before starting any wellness protocol.

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